Publications

2019

Minhaj Alam, David Le, Jennifer I. Lim, Devrim Toslak, Xincheng Yao, “Supervised machine learning based multi-task artificial intelligence classification of retinopathies,” Journal of Clinical Medicine (2019) (Accepted, in press).

Y. T. Hsieh, M. N. Alam, D. Le, C. C. Hsiao, C. H. Yang, D. Chao, and X Yao. Optical Coherence Tomography Angiography Biomarkers for Predicting Visual Outcomes after Ranibizumab Treatment for Diabetic Macular Edema, Ophthalmology Retina, in press (2019) [Full text]

C. Liu, B. Pazzucconi, J. Liu, L. Liu, and X Yao. A holographic waveguide based eye tracker. Journal of Modern Optics, in press (2019) [Full text]

T. H. Kim, T. Son, and X. Yao, “Functional OCT angiography reveals early physiological dysfunction of hyaloid vasculature in developing mouse eye”. Experimental Biology and Medicine, in press (2019)

T. Son, M. Alam, T. H. Kim, C. Liu, D. Toslak, and X. Yao, “Near infrared oximetry guided artery-vein classification in optical coherence tomography angiography”. Experimental Biology and Medicine, in press (2019)

D. Le, M. Alam, B. A. Miao, J. I. Lim, and X. Yao, “Fully automated geometric feature analysis in optical coherence tomography angiography for objective classification of diabetic retinopathy”. Biomedical Optics Express, 10(5): 2493-2503 (2019)

M. Alam, D. Toslak, J. I. Lim, and X. Yao, “ OCT feature analysis guided artery-vein differentiation in OCTA ”. Biomedical Optics Express 10(4): 2055-2066 (2019) [Full Text]

M. Alam, J. I. Lim, D. Toslak, and X. Yao, “Differential artery-vein analysis improves the performance of OCTA staging of sickle cell retinopathy”. Translational Vision Science & Technology, 8(3) (2019) [Full Text]

M. Alam, Y. Zhang, J. I. Lim, R. Chan, M. Yang, and X. Yao, “Quantitative OCT angiography features for objective classification and staging of diabetic retinopathy”. Retina (Philadelphia, Pa.) [Full Text].

Jin, X. Ding, J. Tan, X. Yao, C. Shen, X. Zhou, C. Tan, S. Liu, and Z. Liu “Structured illumination imaging without grating rotation based on mirror operation on 1D Fourier spectrum”, Optics Express 27 (3): 2016-2028 (2019) [Full Text]

2018

X. Yao, T. Son, T. H. Kim, and Y. Lu, “Functional optical coherence tomography of retinal photoreceptors”. Experimental Biology and Medicine 243: 1254–1262 (2018) [Full Text]

Y. Lu, J. Benedetti, and X. Yao, “Light-induced length shrinkage of rod photoreceptor outer segments”. Translational vision science & technology 7 (6), 29 (2018) [Full Text]

T. H. Kim, T. Son, Y. Lu, M. Alam, and X. Yao, “Comparative optical coherence tomography angiography of wild-type and rd10 mouse retinas”. Translational vision science & technology 7 (6), 42 (2018) [Full Text]

M. Alam, D. Toslak, J. I. Lim, and X. Yao, “Color fundus image guided artery-vein differentiation in optical coherence tomography angiography”. Invest Ophthalmol Vis Sci 59, 4953-4962 (2018) [Full Text]

B. Wang, D. Toslak, M. Alam, and X. Yao, “Contact-free trans-pars-planar illumination enables snapshot fundus camera for nonmydriatic wide field photography”. Scientific Reports, 8, 8768 (2018) [Full Text]

T. Son, M. Alam, D. Toslak, B. Wang, Y. Lu, and X. Yao, “Functional optical coherence tomography of neurovascular coupling interactions in the retina”. Journal of Biophotonics, e201800089 (2018) [Full Text]

Y. Lu, C. Liu, and X. Yao, “In vivo super-resolution imaging of transient retinal phototropism evoked by oblique light stimulation”. Journal of Biomedical Optics23(5), 050502 (2018) [Full Text]

D. Toslak, A. C. Liu, M. N. Alam, and X. Yao. “Near infrared light guided miniaturized indirect ophthalmoscopy for nonmydriatic wide-field fundus photography”. Optics Letters 43 (11) 2551-2554 (2018) [Full Text]

M. Alam, T. Son, D. Toslak, J. I. Lim, and X. Yao, “Combining optical density ratio and blood vessel tracking for automated artery-vein classification and quantitative analysis in color fundus images”. Translational Vision Science & Technology (TVST) 7(2): 23 (2018) [Full Text]

D. Toslak, A. Ayata, C. Liu, M. K. Erol, and X. Yao. “Wide-field smartphone fundus video camera based on miniaturized indirect ophthalmoscopy”. Retina (Philadelphia, Pa.), 38(2), 438-441(2018). [Full Text]

2017

M, Alam, D. Thapa, J. I. Lim, D. Cao, and X. Yao. Computer-aided classification of sickle cell retinopathy using quantitative features in optical coherence tomography angiography. Biomedical Optics Express 8(9), 4206-4216 (2017) [Full Text]

D. Thapa, B. Wang, Y. Lu, T. Son, and X. Yao. Enhancement of intrinsic optical signal recording with split spectrum optical coherence tomography. Journal of Modern Optics (2017) [Full Text]

C. Liu, D. Thapa, and X. Yao. Digital adaptive optics confocal microscopy based on iterative retrieval of optical aberration from a guidestar hologram. Optics Express 25(7), 8223-8236 (2017) [Full Text]

M, Alam, D. Thapa, J. I. Lim, D. Cao, and X. Yao. Quantitative characteristics of sickle cell retinopathy in optical coherence tomography angiography. Biomedical Optics Express 8(3) 1741-1753 [Full Text]

D. Toslak, D. Thapa, M. K. Erol, Y. Chen, and X. Yao. Smartphone-based imaging of the corneal endothelium at sub-cellular resolution. Journal of Modern Optics(2017) [Full Text]

Y. Lu, B. Wang, D. R. Pepperberg, and X. Yao. Stimulus-evoked outer segment changes occur before the hyperpolarization of retinal photoreceptors. Biomedical Optics Express 8 (1), 38-47 (2017) [Full Text]

2016

C. Liu, Y. Zhi, B. Wang, D. Thapa, Y. Chen, M. Alam, Y. Lu and X. Yao. In vivo super-resolution retinal imaging through virtually structured detection. Journal of Biomedical Optics 21 (12), 120502-120502 (2016) [Full Text]

B. Wang, Y. Lu, and X. Yao. In vivo optical coherence tomography of stimulus evoked intrinsic optical signals in mouse retinas. Journal of Biomedical Optics 21(9), 096010 (2016) [Full Text]

T. Son, B. Wang, D. Thapa, Y. Lu, Y. Chen, D. Cao, and X. Yao, Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers. Biomedical Optics Express 8, 3151-3162 (2016) [Full Text]

X. Zhao, D. Thapa, B. Wang, Y. Lu, S. Gai, X. Yao. Stimulus-evoked outer segment changes in rod photoreceptors. Journal of Biomedical Optics 21(6), 065006 (2016) [Full Text]

D. Toslak, D. Thapa, Y.Chen, M. K. Erol, R.V. Paul Chan, and X.Yao. Trans-palpebral illumination: an approach for wide-angle fundus photography without the need for pupil dilation. Optics Letters 41, 2688-2691 (2016) [Full Text]

Y. Wang, P. Chen, L. Sun, X. Yao, W. Liu, and L. Lin, Detecting trace amounts of narcotics in serum by delayed luminescence. IEEE Photonics Journal 8, 6802208 (2016) [Full Text]

2015

Y. Zhi, B. Wang, and X. Yao, Super-resolution scanning laser microscopy based on virtually structured detection. Critical Reviews in Biomedical Engineering 43, 297-322 (2015) [Full Text]

X. Yao and B. Wang, Intrinsic optical signal imaging of retinal physiology: a review. Journal of Biomedical Optics 20, 090901 (2015) [Full Text].

B. C. Liu, L. L. Yang, X. Y. Lu, X. Song, X. C. Li, G. Chen, Y. Li, X. Yao, D. R. Humphrey, D. C. Eaton, B. Z. Shen, and H. P. Ma. Lovastatin-Induced Phosphatidylinositol-4-Phosphate 5-Kinase Diffusion from Microvilli Stimulates ROMK Channels. J Am Soc Nephrol 26, 1576-1587 (2015) [Full Text]

Q.X. Zhang, R.W. Lu, B.Q. Wang, J. D. Messinger, C. A. Curcio, and X.C. Yao. Functional optical coherence tomography enables in vivo physiological assessment of retinal rod and cone photoreceptors, Scientific Reports 5, 9595 (2015) [Full Text]

Y. Zhi, R. Lu, B. Wang, Q. Zhang, and X.C. Yao. Rapid super-resolution line scanning microscopy through virtually structured detection. Optics Letters 40, 1683-1686 (2015) [Full Text]

J. Han, J. Liu, X.C. Yao, and Y. Wang. A portable waveguide display system with a large field of view by integrating freeform elements and volume holograms. Optics Express 23, 3534-3549 (2015) [Full Text]

R. Lu, Y. Zhi, B. Wang, Q. Zhang, and X.C. Yao. A polarization-sensitive light field imager for multi-channel angular spectroscopy of light scattering in biological tissues. Quantitative Imaging in Medicine and Surgery 5, 1-8 (2015) [Full Text]

1999-2014

B. Wang, R. Lu, Q. Zhang, and X.C. Yao. Functional optical coherence tomography reveals transient phototropic change of photoreceptor outer segments. Optics Letters 39, 6923–6926 (2014) [Full Text]

B.Q. Wang, R.W. Lu, Q.X. Zhang and X.C. Yao. Breaking diffraction limit of lateral resolution in optical coherence tomography, Quantitative Imaging in Medicine and Surgery 3, 243-248 (2013) [Full Text]

B.Q. Wang, R.W. Lu, Q.X. Zhang, Y.Q. Jiang and X.C. Yao. Enface optical coherence tomography of transient light response at photoreceptor outer segments in living frog eyecup, Optics Letters 38, 4526-4529(2013) [Full Text]

R.W. Lu, A.L. Levy, Q.X. Zhang, S. Pittler and X.C. Yao. Dynamic near infrared imaging reveals transient phototropic change in retinal rod photoreceptors, Journal of Biomedical Optics 18, 106013 (2013) [Full Text]

Q.X. Zhang, R.W. Lu, J. D. Messinger, C. A. Curcio, V. Guarcello, and X.C. Yao. In vivo optical coherence tomography of light-driven melanosome translocation in retinal pigment epithelium, Scientific Reports 3, 2644 (2013) [Full Text]

R.W. Lu, B.Q. Wang, Q.X. Zhang, and X.C. Yao. Super-resolution scanning laser microscopy through virtually structured detection, Biomedical Optics Express 4, 1673-1682 (2013) [Full Text]

Q.X. Zhang, R.W. Lu, C. A. Curcio, and X. C. Yao. In vivo confocal intrinsic optical signal identification of localized retinal dysfunction. Invest Ophthalmol Vis Sci53(13):8139-8145 (2012) (Full Text)

R.W. Lu, C. A. Curcio, Y. Zhang, Q.X. Zhang, S. J. Pittler, D. Deretic, and X. C. Yao. Investigation of the hyper-reflective inner/outer segment band in optical coherence tomography of living frog retina. Journal of Biomedical Optics 17, 060504 (2012) [Full Text]

Y.C. Li, J. M. Luo, R.W. Lu, K. M. Liu, A. M. Levy, and X.C. Yao. Dynamic intrinsic optical signal monitoring of electrically stimulated inner retinal neural response.Journal of Modern Optics 59, 967-971 (2012) [Full Text]

X.C. Yao, W.X. Cui, Y.C. Li, W. Zhang, R.W. Lu, A. Thompson, F. Amthor, and X.J. Wang. Functional imaging of glucose-evoked rat islet activities using transient intrinsic optical signals. Journal of Modern Optics 59, 843-847 (2012) [Full Text]

Q.X. Zhang, Y. Zhang, R.W. Lu, Y. C. Li, S. J. Pittler, T. W. Kraft, and X. C. Yao. Comparative intrinsic optical signal imaging of wild-type and mutant mouse retinas. Optics Express 20,7646-7654 (2012) [Full Text]

X. C. Yao, and Y. C. Li, Functional imaging of retinal photoreceptors and inner neurons using stimulus-evoked intrinsic optical signals, Methods Mol Biol 884, 277-285 (2012).[Full Text]

Q.X. Zhang, R.W. Lu, Y. G. Li and X. C. Yao. In vivo confocal imaging of fast intrinsic optical signals correlated with frog retinal activation. Optics letters 36, 4692-4694 (2011) [Full Text]

R.W. Lu, Y.C. Li, T. Ye, C. Strang, K. Keyser, C. A. Curcio, and X.C. Yao. Two-photon excited autofluorescence imaging of freshly isolated frog retinas, Biomedical Optics Express 2, 1494-1503 (2011) [Full Text]

R.W. Lu, Q. X. Zhang, and X. C. Yao. Circular polarization intrinsic optical signal recording of stimulus-evoked neural activity, Optics letters 36, 1866-1868 (2011) [Full Text]

Y.C. Li, W.X. Cui, X.J. Wang, F. Amthor, R.W. Lu, A. Thompson, and X.C. Yao. Intrinsic optical signal imaging of glucose-stimulated insulin secreting β-cells, Optics Express 19,  99-106 (2011) [Full Text]

Q. X. Zhang, J. Y. Wang, L. Liu, and X. C. Yao. Microlens array recording of localized retinal responses, Optics letters 35, 3838-3840 (2010) [Full Text]

Y. C. Li, C. Strang, F. R. Amthor, L. Liu, Y. G. Li,  Q. X. Zhang, K. Keyser, and X. C. Yao. Parallel optical monitoring of visual signal propagation from the photoreceptors to inner retina layers, Optics letters 35, 1810–1812 (2010) [Full Text]

Y. G. Li, Q.X. Zhang, L. Liu, F. Amthor, and X. C. Yao. High spatiotemporal resolution imaging of fast intrinsic optical signals activated by retinal flicker stimulation, Optics Express 18, 7210-7218 (2010) [Full Text]

Y. G. Li, L. Liu, F. Amthor, and X. C. Yao. High speed line-scan confocal imaging of stimulus-evoked intrinsic optical signals in the retina, Optics letters 35,426-428 (2010) [Full text]

X. C. Yao. Intrinsic optical signal imaging of retinal activation, Japanese Journal of Ophthalmology. Japanese Journal of Ophthalmology53, 327-333 (2009, invited review) [Full Text]

X. C. Yao, L. Liu, and Y. G. Li, Intrinsic optical signal imaging of retinal activity in frog eye, Journal of Innovative Optical Health Sciences 2, 201–208 (2009) [Full Text]

X. C. Yao and Y. B. Zhao. Optical dissection of stimulus-evoked retinal activation, Optics Express 16, 12446-12459 (2008) [Full Text]

J. L. Schei, M. D. McCluskey, A. J. Foust, X. C. Yao, and D. M. Rector, Action potential propagation imaged with high temporal resolution near-infrared video microscopy and polarized light, Neuroimage 40, 1034-1043 (2008).[Full Text]

Y.B. Zhao and X.C. Yao. Intrinsic optical imaging of stimulus-modulated physiological responses in amphibian retina. Optics Letters 33, 342-344 (2008) [Full Text]

X.C. Yao and J.S. George. Near infrared imaging of fast intrinsic optical responses in visible light-activated amphibian retina. Journal of Biomedical Optics11, 064030 (2006)

X.C. Yao and J.S. George. Dynamic neuroimaging of retinal light responses using fast intrinsic optical signals. Neuroimage. 33:898-906 (2006)

X.C. Yao, A. Foust, D.M. Rector, B. Barrowes and J.S. George. Cross-polarized reflected light measurement of fast optical responses associated with neural activation. Biophysical Journal 88, 4170-4177. (2005)

X.C. Yao, A.M. Yamauchi, B. Perry and J.S. George. Rapid optical coherence tomography and recording scattering changes from activated frog retina. Applied Optics 44, 2019-2023. (2005)

X.C. Yao and D.Z. Zhang. Micro-rotation by flow-induced torque in an optical trap. Optical Review 11, 4-6. (2004)

X.C. Yao and A. Castro. Optical trapping microfabrication using electrophoretically-delivered particles inside glass capillaries. Optics Letter 28, 1335-1337. (2003)

X.C. Yao, D.M. Rector and J.S. George. Optical lever recording of displacements from activated lobster nerve bundles and Nitella internodes. Applied Optics 42, 2972-2978. (2003)

H.L. Guo, X.C. Yao, Z.L. Li, X.H. Han, B.Y. Cheng and D.Z. Zhang. Measurements of displacement and trapping force on micron-sized particles in optical tweezers system. Science in China (Series A) 45, 919-925. (2002)

H.L. Guo, X.C. Yao, Z.L. Li, X.H. Han, B.Y. Cheng and D.Z. Zhang. Measurements of displacement and trapping force on micron-sized particles in optical tweezers system. Science in China (Series A) (Chinese Version) 32, 97-102. (2002)

X.C. Yao, Z.L. Li, H.L. Guo, B.Y. Cheng and D.Z. Zhang. A new method with CCD subpixel resolution. Chinese Journal of Scientific Instrument 23, 60-63. (2002)

X.C. Yao, Z.L. Li, H.L. Guo, B.Y. Cheng, X.H. Han and D.Z. Zhang. Study on optical trap steering system. Optics and precision engineering 9, 55-58. (2001)

X.C. Yao, Z.L. Li, H.L. Guo, B.Y. Cheng, D.Z. Zhang. Effects of spherical aberration on optical trapping forces for Rayleigh particles. Chinese Physics Letter18, 432-434. (2001)

X.C. Yao, Z.L. Li, H.L. Guo, B.Y. Cheng, X.H. Han and D.Z. Zhang. Effect of spherical aberration introduction by water solution on trapping force. Chinese Physics 9, 824-826. (2000)

X.C. Yao, Z.L. Li, B.Y. Cheng, X.H. Han and D.Z. Zhang. Increasing transverse stability of optical tweezers by using dual-Gaussian beam profile. Chinese Physics9, 65-68. (2000)

X.C. Yao, Z.L. Li, B.Y. Cheng and D.Z. Zhang. Analysis and calculation of the optical force on a double-layer dielectric sphere. Acta Optica Sinica 20, 1305-1310. (2000)

S.W. Xu, X.C. Yao, L. Fu. Analysis for the influence of image motion on push-broom TDI-CCD imaging. Opto-Electroic Engineering 26, 60-63. (1999)

Book chapters:

  1. X. C. Yao. ‘Intrinsic optical signal imaging of stimulus-evoked activities in the retina’. in Advanced Biophotonics: slicing tissue with photons. Ed. Valery Tuchin and Ricky Wang. (2012)
  2. D. M. Rector, X. C. Yao, R. M. Harper, and J. S. George. ‘In-Vivo Observations of Rapid Scattered Light Changes Associated with Electrical Events’. in In Vivo Optical Imaging of Brain Function, Second Edition (Frontiers in Neuroscience).,Ed. Ron Frostig (2009)