Publications

2020

Yao, Xincheng, Minhaj N Alam, David Le, and Devrim Toslak. “Quantitative Optical Coherence Tomography Angiography: A Review.” Experimental Biology and Medicine, (January 2020). [Full text]

M. Alam, Y. Zhang, J. I. Lim, R. Chan, M. Yang, and X. Yao, “Quantitative optical coherence tomography angiography features for objective classification and staging of diabetic retinopathy”. Retina 40 (2), 322-332 (2020), [Full Text].

Devrim Toslak, Felix Chau, Muhammet Kazim Erol, Changgeng Liu, R. V. Paul Chan, Taeyoon Son, and Xincheng Yao, “Trans-pars-planar illumination enables a 200° ultra-wide field pediatric fundus camera for easy examination of the retina,” Biomed. Opt. Express 11, 68-76 (2020) [Full text].

2019

Y. Lu, T. H. Kim, and X. Yao, “Comparative study of wild-type and rd10 mice reveals transient intrinsic optical signal response before phosphodiesterase activation in retinal photoreceptors”. Experimental Biology and Medicine, in press (2019) [Full text]

Kim, T., Son, T., Le, D., and Yao, X. et al. Longitudinal OCT and OCTA monitoring reveals accelerated regression of hyaloid vessels in retinal degeneration 10 (rd10) mice. Sci Rep 9, 16685 (2019) doi:10.1038/s41598-019-53082-9 [Full text].

Minhaj Alam, David Le, Jennifer I. Lim, R.V.P. Chan, Xincheng Yao, “Supervised machine learning based multi-task artificial intelligence classification of retinopathies,” Journal of Clinical Medicine (2019) [Full text].

Y. T. Hsieh, M. N. Alam, D. Le, C. C. Hsiao, C. H. Yang, D. Chao, and X Yao. Optical Coherence Tomography Angiography Biomarkers for Predicting Visual Outcomes after Ranibizumab Treatment for Diabetic Macular Edema, Ophthalmology Retina , Volume 3, Issue 10, 826 – 834 (2019) [Full text]

C. Liu, B. Pazzucconi, J. Liu, L. Liu, and X Yao. A holographic waveguide based eye tracker. Journal of Modern Optics, in press (2019) [Full text]

T. H. Kim, T. Son, and X. Yao, “Functional OCT angiography reveals early physiological dysfunction of hyaloid vasculature in developing mouse eye”. Experimental Biology and Medicine, in press (2019) [Full text]

T. Son, M. Alam, T. H. Kim, C. Liu, D. Toslak, and X. Yao, “Near infrared oximetry guided artery-vein classification in optical coherence tomography angiography”. Experimental Biology and Medicine, in press (2019) [Full text]

D. Le, M. Alam, B. A. Miao, J. I. Lim, and X. Yao, “Fully automated geometric feature analysis in optical coherence tomography angiography for objective classification of diabetic retinopathy”. Biomedical Optics Express, 10(5): 2493-2503 (2019) [Full text]

M. Alam, D. Toslak, J. I. Lim, and X. Yao, “ OCT feature analysis guided artery-vein differentiation in OCTA ”. Biomedical Optics Express 10(4): 2055-2066 (2019) [Full Text]

M. Alam, J. I. Lim, D. Toslak, and X. Yao, “Differential artery-vein analysis improves the performance of OCTA staging of sickle cell retinopathy”. Translational Vision Science & Technology, 8(3) (2019) [Full Text]

Jin, X. Ding, J. Tan, X. Yao, C. Shen, X. Zhou, C. Tan, S. Liu, and Z. Liu “Structured illumination imaging without grating rotation based on mirror operation on 1D Fourier spectrum”, Optics Express 27 (3): 2016-2028 (2019) [Full Text]

2018

X. Yao, T. Son, T. H. Kim, and Y. Lu, “Functional optical coherence tomography of retinal photoreceptors”. Experimental Biology and Medicine 243: 1254–1262 (2018) [Full Text]

Y. Lu, J. Benedetti, and X. Yao, “Light-induced length shrinkage of rod photoreceptor outer segments”. Translational vision science & technology 7 (6), 29 (2018) [Full Text]

T. H. Kim, T. Son, Y. Lu, M. Alam, and X. Yao, “Comparative optical coherence tomography angiography of wild-type and rd10 mouse retinas”. Translational vision science & technology 7 (6), 42 (2018) [Full Text]

M. Alam, D. Toslak, J. I. Lim, and X. Yao, “Color fundus image guided artery-vein differentiation in optical coherence tomography angiography”. Invest Ophthalmol Vis Sci 59, 4953-4962 (2018) [Full Text]

B. Wang, D. Toslak, M. Alam, and X. Yao, “Contact-free trans-pars-planar illumination enables snapshot fundus camera for nonmydriatic wide field photography”. Scientific Reports, 8, 8768 (2018) [Full Text]

T. Son, M. Alam, D. Toslak, B. Wang, Y. Lu, and X. Yao, “Functional optical coherence tomography of neurovascular coupling interactions in the retina”. Journal of Biophotonics, e201800089 (2018) [Full Text]

Y. Lu, C. Liu, and X. Yao, “In vivo super-resolution imaging of transient retinal phototropism evoked by oblique light stimulation”. Journal of Biomedical Optics23(5), 050502 (2018) [Full Text]

D. Toslak, A. C. Liu, M. N. Alam, and X. Yao. “Near infrared light guided miniaturized indirect ophthalmoscopy for nonmydriatic wide-field fundus photography”. Optics Letters 43 (11) 2551-2554 (2018) [Full Text]

M. Alam, T. Son, D. Toslak, J. I. Lim, and X. Yao, “Combining optical density ratio and blood vessel tracking for automated artery-vein classification and quantitative analysis in color fundus images”. Translational Vision Science & Technology (TVST) 7(2): 23 (2018) [Full Text]

D. Toslak, A. Ayata, C. Liu, M. K. Erol, and X. Yao. “Wide-field smartphone fundus video camera based on miniaturized indirect ophthalmoscopy”. Retina (Philadelphia, Pa.), 38(2), 438-441(2018). [Full Text]

2017

M, Alam, D. Thapa, J. I. Lim, D. Cao, and X. Yao. Computer-aided classification of sickle cell retinopathy using quantitative features in optical coherence tomography angiography. Biomedical Optics Express 8(9), 4206-4216 (2017) [Full Text]

D. Thapa, B. Wang, Y. Lu, T. Son, and X. Yao. Enhancement of intrinsic optical signal recording with split spectrum optical coherence tomography. Journal of Modern Optics (2017) [Full Text]

C. Liu, D. Thapa, and X. Yao. Digital adaptive optics confocal microscopy based on iterative retrieval of optical aberration from a guidestar hologram. Optics Express 25(7), 8223-8236 (2017) [Full Text]

M, Alam, D. Thapa, J. I. Lim, D. Cao, and X. Yao. Quantitative characteristics of sickle cell retinopathy in optical coherence tomography angiography. Biomedical Optics Express 8(3) 1741-1753 [Full Text]

D. Toslak, D. Thapa, M. K. Erol, Y. Chen, and X. Yao. Smartphone-based imaging of the corneal endothelium at sub-cellular resolution. Journal of Modern Optics(2017) [Full Text]

Y. Lu, B. Wang, D. R. Pepperberg, and X. Yao. Stimulus-evoked outer segment changes occur before the hyperpolarization of retinal photoreceptors. Biomedical Optics Express 8 (1), 38-47 (2017) [Full Text]

2016

C. Liu, Y. Zhi, B. Wang, D. Thapa, Y. Chen, M. Alam, Y. Lu and X. Yao. In vivo super-resolution retinal imaging through virtually structured detection. Journal of Biomedical Optics 21 (12), 120502-120502 (2016) [Full Text]

B. Wang, Y. Lu, and X. Yao. In vivo optical coherence tomography of stimulus evoked intrinsic optical signals in mouse retinas. Journal of Biomedical Optics 21(9), 096010 (2016) [Full Text]

T. Son, B. Wang, D. Thapa, Y. Lu, Y. Chen, D. Cao, and X. Yao, Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers. Biomedical Optics Express 8, 3151-3162 (2016) [Full Text]

X. Zhao, D. Thapa, B. Wang, Y. Lu, S. Gai, X. Yao. Stimulus-evoked outer segment changes in rod photoreceptors. Journal of Biomedical Optics 21(6), 065006 (2016) [Full Text]

D. Toslak, D. Thapa, Y.Chen, M. K. Erol, R.V. Paul Chan, and X.Yao. Trans-palpebral illumination: an approach for wide-angle fundus photography without the need for pupil dilation. Optics Letters 41, 2688-2691 (2016) [Full Text]

Y. Wang, P. Chen, L. Sun, X. Yao, W. Liu, and L. Lin, Detecting trace amounts of narcotics in serum by delayed luminescence. IEEE Photonics Journal 8, 6802208 (2016) [Full Text]

2015

Y. Zhi, B. Wang, and X. Yao, Super-resolution scanning laser microscopy based on virtually structured detection. Critical Reviews in Biomedical Engineering 43, 297-322 (2015) [Full Text]

X. Yao and B. Wang, Intrinsic optical signal imaging of retinal physiology: a review. Journal of Biomedical Optics 20, 090901 (2015) [Full Text].

B. C. Liu, L. L. Yang, X. Y. Lu, X. Song, X. C. Li, G. Chen, Y. Li, X. Yao, D. R. Humphrey, D. C. Eaton, B. Z. Shen, and H. P. Ma. Lovastatin-Induced Phosphatidylinositol-4-Phosphate 5-Kinase Diffusion from Microvilli Stimulates ROMK Channels. J Am Soc Nephrol 26, 1576-1587 (2015) [Full Text]

Q.X. Zhang, R.W. Lu, B.Q. Wang, J. D. Messinger, C. A. Curcio, and X.C. Yao. Functional optical coherence tomography enables in vivo physiological assessment of retinal rod and cone photoreceptors, Scientific Reports 5, 9595 (2015) [Full Text]

Y. Zhi, R. Lu, B. Wang, Q. Zhang, and X.C. Yao. Rapid super-resolution line scanning microscopy through virtually structured detection. Optics Letters 40, 1683-1686 (2015) [Full Text]

J. Han, J. Liu, X.C. Yao, and Y. Wang. A portable waveguide display system with a large field of view by integrating freeform elements and volume holograms. Optics Express 23, 3534-3549 (2015) [Full Text]

R. Lu, Y. Zhi, B. Wang, Q. Zhang, and X.C. Yao. A polarization-sensitive light field imager for multi-channel angular spectroscopy of light scattering in biological tissues. Quantitative Imaging in Medicine and Surgery 5, 1-8 (2015) [Full Text]

1999-2014

B. Wang, R. Lu, Q. Zhang, and X.C. Yao. Functional optical coherence tomography reveals transient phototropic change of photoreceptor outer segments. Optics Letters 39, 6923–6926 (2014) [Full Text]

B.Q. Wang, R.W. Lu, Q.X. Zhang and X.C. Yao. Breaking diffraction limit of lateral resolution in optical coherence tomography, Quantitative Imaging in Medicine and Surgery 3, 243-248 (2013) [Full Text]

B.Q. Wang, R.W. Lu, Q.X. Zhang, Y.Q. Jiang and X.C. Yao. Enface optical coherence tomography of transient light response at photoreceptor outer segments in living frog eyecup, Optics Letters 38, 4526-4529(2013) [Full Text]

R.W. Lu, A.L. Levy, Q.X. Zhang, S. Pittler and X.C. Yao. Dynamic near infrared imaging reveals transient phototropic change in retinal rod photoreceptors, Journal of Biomedical Optics 18, 106013 (2013) [Full Text]

Q.X. Zhang, R.W. Lu, J. D. Messinger, C. A. Curcio, V. Guarcello, and X.C. Yao. In vivo optical coherence tomography of light-driven melanosome translocation in retinal pigment epithelium, Scientific Reports 3, 2644 (2013) [Full Text]

R.W. Lu, B.Q. Wang, Q.X. Zhang, and X.C. Yao. Super-resolution scanning laser microscopy through virtually structured detection, Biomedical Optics Express 4, 1673-1682 (2013) [Full Text]

Q.X. Zhang, R.W. Lu, C. A. Curcio, and X. C. Yao. In vivo confocal intrinsic optical signal identification of localized retinal dysfunction. Invest Ophthalmol Vis Sci53(13):8139-8145 (2012) (Full Text)

R.W. Lu, C. A. Curcio, Y. Zhang, Q.X. Zhang, S. J. Pittler, D. Deretic, and X. C. Yao. Investigation of the hyper-reflective inner/outer segment band in optical coherence tomography of living frog retina. Journal of Biomedical Optics 17, 060504 (2012) [Full Text]

Y.C. Li, J. M. Luo, R.W. Lu, K. M. Liu, A. M. Levy, and X.C. Yao. Dynamic intrinsic optical signal monitoring of electrically stimulated inner retinal neural response.Journal of Modern Optics 59, 967-971 (2012) [Full Text]

X.C. Yao, W.X. Cui, Y.C. Li, W. Zhang, R.W. Lu, A. Thompson, F. Amthor, and X.J. Wang. Functional imaging of glucose-evoked rat islet activities using transient intrinsic optical signals. Journal of Modern Optics 59, 843-847 (2012) [Full Text]

Q.X. Zhang, Y. Zhang, R.W. Lu, Y. C. Li, S. J. Pittler, T. W. Kraft, and X. C. Yao. Comparative intrinsic optical signal imaging of wild-type and mutant mouse retinas. Optics Express 20,7646-7654 (2012) [Full Text]

X. C. Yao, and Y. C. Li, Functional imaging of retinal photoreceptors and inner neurons using stimulus-evoked intrinsic optical signals, Methods Mol Biol 884, 277-285 (2012).[Full Text]

Q.X. Zhang, R.W. Lu, Y. G. Li and X. C. Yao. In vivo confocal imaging of fast intrinsic optical signals correlated with frog retinal activation. Optics letters 36, 4692-4694 (2011) [Full Text]

R.W. Lu, Y.C. Li, T. Ye, C. Strang, K. Keyser, C. A. Curcio, and X.C. Yao. Two-photon excited autofluorescence imaging of freshly isolated frog retinas, Biomedical Optics Express 2, 1494-1503 (2011) [Full Text]

R.W. Lu, Q. X. Zhang, and X. C. Yao. Circular polarization intrinsic optical signal recording of stimulus-evoked neural activity, Optics letters 36, 1866-1868 (2011) [Full Text]

Y.C. Li, W.X. Cui, X.J. Wang, F. Amthor, R.W. Lu, A. Thompson, and X.C. Yao. Intrinsic optical signal imaging of glucose-stimulated insulin secreting β-cells, Optics Express 19,  99-106 (2011) [Full Text]

Q. X. Zhang, J. Y. Wang, L. Liu, and X. C. Yao. Microlens array recording of localized retinal responses, Optics letters 35, 3838-3840 (2010) [Full Text]

Y. C. Li, C. Strang, F. R. Amthor, L. Liu, Y. G. Li,  Q. X. Zhang, K. Keyser, and X. C. Yao. Parallel optical monitoring of visual signal propagation from the photoreceptors to inner retina layers, Optics letters 35, 1810–1812 (2010) [Full Text]

Y. G. Li, Q.X. Zhang, L. Liu, F. Amthor, and X. C. Yao. High spatiotemporal resolution imaging of fast intrinsic optical signals activated by retinal flicker stimulation, Optics Express 18, 7210-7218 (2010) [Full Text]

Y. G. Li, L. Liu, F. Amthor, and X. C. Yao. High speed line-scan confocal imaging of stimulus-evoked intrinsic optical signals in the retina, Optics letters 35,426-428 (2010) [Full text]

X. C. Yao. Intrinsic optical signal imaging of retinal activation, Japanese Journal of Ophthalmology. Japanese Journal of Ophthalmology53, 327-333 (2009, invited review) [Full Text]

X. C. Yao, L. Liu, and Y. G. Li, Intrinsic optical signal imaging of retinal activity in frog eye, Journal of Innovative Optical Health Sciences 2, 201–208 (2009) [Full Text]

X. C. Yao and Y. B. Zhao. Optical dissection of stimulus-evoked retinal activation, Optics Express 16, 12446-12459 (2008) [Full Text]

J. L. Schei, M. D. McCluskey, A. J. Foust, X. C. Yao, and D. M. Rector, Action potential propagation imaged with high temporal resolution near-infrared video microscopy and polarized light, Neuroimage 40, 1034-1043 (2008).[Full Text]

Y.B. Zhao and X.C. Yao. Intrinsic optical imaging of stimulus-modulated physiological responses in amphibian retina. Optics Letters 33, 342-344 (2008) [Full Text]

X.C. Yao and J.S. George. Near infrared imaging of fast intrinsic optical responses in visible light-activated amphibian retina. Journal of Biomedical Optics11, 064030 (2006)

X.C. Yao and J.S. George. Dynamic neuroimaging of retinal light responses using fast intrinsic optical signals. Neuroimage. 33:898-906 (2006)

X.C. Yao, A. Foust, D.M. Rector, B. Barrowes and J.S. George. Cross-polarized reflected light measurement of fast optical responses associated with neural activation. Biophysical Journal 88, 4170-4177. (2005)

X.C. Yao, A.M. Yamauchi, B. Perry and J.S. George. Rapid optical coherence tomography and recording scattering changes from activated frog retina. Applied Optics 44, 2019-2023. (2005)

X.C. Yao and D.Z. Zhang. Micro-rotation by flow-induced torque in an optical trap. Optical Review 11, 4-6. (2004)

X.C. Yao and A. Castro. Optical trapping microfabrication using electrophoretically-delivered particles inside glass capillaries. Optics Letter 28, 1335-1337. (2003)

X.C. Yao, D.M. Rector and J.S. George. Optical lever recording of displacements from activated lobster nerve bundles and Nitella internodes. Applied Optics 42, 2972-2978. (2003)

H.L. Guo, X.C. Yao, Z.L. Li, X.H. Han, B.Y. Cheng and D.Z. Zhang. Measurements of displacement and trapping force on micron-sized particles in optical tweezers system. Science in China (Series A) 45, 919-925. (2002)

H.L. Guo, X.C. Yao, Z.L. Li, X.H. Han, B.Y. Cheng and D.Z. Zhang. Measurements of displacement and trapping force on micron-sized particles in optical tweezers system. Science in China (Series A) (Chinese Version) 32, 97-102. (2002)

X.C. Yao, Z.L. Li, H.L. Guo, B.Y. Cheng and D.Z. Zhang. A new method with CCD subpixel resolution. Chinese Journal of Scientific Instrument 23, 60-63. (2002)

X.C. Yao, Z.L. Li, H.L. Guo, B.Y. Cheng, X.H. Han and D.Z. Zhang. Study on optical trap steering system. Optics and precision engineering 9, 55-58. (2001)

X.C. Yao, Z.L. Li, H.L. Guo, B.Y. Cheng, D.Z. Zhang. Effects of spherical aberration on optical trapping forces for Rayleigh particles. Chinese Physics Letter18, 432-434. (2001)

X.C. Yao, Z.L. Li, H.L. Guo, B.Y. Cheng, X.H. Han and D.Z. Zhang. Effect of spherical aberration introduction by water solution on trapping force. Chinese Physics 9, 824-826. (2000)

X.C. Yao, Z.L. Li, B.Y. Cheng, X.H. Han and D.Z. Zhang. Increasing transverse stability of optical tweezers by using dual-Gaussian beam profile. Chinese Physics9, 65-68. (2000)

X.C. Yao, Z.L. Li, B.Y. Cheng and D.Z. Zhang. Analysis and calculation of the optical force on a double-layer dielectric sphere. Acta Optica Sinica 20, 1305-1310. (2000)

S.W. Xu, X.C. Yao, L. Fu. Analysis for the influence of image motion on push-broom TDI-CCD imaging. Opto-Electroic Engineering 26, 60-63. (1999)

Book chapters:

  1. X. C. Yao. ‘Intrinsic optical signal imaging of stimulus-evoked activities in the retina’. in Advanced Biophotonics: slicing tissue with photons. Ed. Valery Tuchin and Ricky Wang. (2012)
  2. D. M. Rector, X. C. Yao, R. M. Harper, and J. S. George. ‘In-Vivo Observations of Rapid Scattered Light Changes Associated with Electrical Events’. in In Vivo Optical Imaging of Brain Function, Second Edition (Frontiers in Neuroscience).,Ed. Ron Frostig (2009)